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Research ingredient or claim substantiation

Have Claude write this prompt first, then run it in Parallel at Ultra depth. The 'skeptical reviewer' role changes what it finds.

by @whitney · recommended tool Parallel AI · 0 unlocks

EXAMPLES · WHAT THIS PROMPT PRODUCES

Sample output

**Substantiation review — Claim: "Bakuchiol firms skin and reduces wrinkles like retinol, without irritation."**

**Rating: MODERATE.** The wrinkle/firming comparison has limited but real clinical support; the "without irritation" portion is better supported than the efficacy equivalence.

**Primary sources**
1. Dhaliwal et al., *Br J Dermatol* 2019 — 12-wk double-blind RCT, bakuchiol vs. retinol: comparable wrinkle/hyperpigmentation improvement, less scaling/stinging. (pubmed.ncbi.nlm.nih.gov/30022486)
2. Chaudhuri & Bojanowski, *Int J Cosmet Sci* 2014 — gene-expression and clinical data on bakuchiol's retinol-like activity. (pubmed.ncbi.nlm.nih.gov/24471735)
3. Bluemke et al., *Clin Cosmet Investig Dermatol* 2022 — tolerability-focused study. (ncbi.nlm.nih.gov/pmc/PMC9270896)
4. Goldberg et al., 2023 split-face tolerability data. 5. PubChem CID 5468522 (compound/safety profile).

**Counter-evidence / caveats**
- Sample sizes are small (n≈44 in the lead RCT); no long-term (>12 wk) data; "like retinol" risks an implied drug claim under FTC scrutiny for a cosmetic.

**Safer marketing framings**
- "A gentle, plant-derived alternative often compared to retinol."
- "Clinically studied for the look of firmer skin, with low reported irritation."
- Avoid "reduces wrinkles" as a standalone; pair with "appearance of."

PRICE HISTORY0 cr · current

PROMPT TEMPLATE · v1.0.0

Research evidence for <CLAIM or INGREDIENT>.
Role: skeptical scientific reviewer.
Source rules: only peer-reviewed journals, FDA, EMA, or cosmetic-chemistry databases.
Deliver:
- The claim, rated strong/moderate/weak/unsupported
- 5 primary sources with URLs
- Counter-evidence or caveats
- Safer alternative framings we could use in marketing.